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目的:通过分析健康受试者口服六味地黄丸后数个重要穴位激光多普勒血流信号的频谱成分,了解口服六味地黄丸对体表微循环血流的影响。方法:对两组男性健康受试者进行激光多普勒血流信号测量。六味地黄丸实验组42名受试者,平均年龄(27.8±3.8)岁;空白实验组28名受试者,平均年龄(27.3±3.4)岁。每次测量实验包含一次20min的基础测量与3次药效测量,其中两次于服药当天进行(口服5g六味地黄丸的浓缩药粉,配合250mL28℃温水服用),另一次测量于服药后第2天进行。结果:在服药后第2天,太溪穴处测量到最明显的平均血流量与脉波血流量增大,此外由频谱分析可发现,0.02～0.06Hz频带的能量比例显著降低,而在其他测量位置,则无任何显著的效应。结论:在口服六味地黄丸之后,体表微循环血流会进行重新分配调整,这可能因于不同体表穴位的血管床和交感神经作用强度不同从而引发微动脉小开口的血流阻力不同。这一非侵入式与实时监控的技术,有助于证实中药的生理效应及其生理作用机制。
OBJECTIVE: To understand the effect of oral Liuweidihuangwan on microcirculation blood flow by analyzing the spectral components of laser Doppler blood flow signals of several important points after oral administration of Liuweidihuang Pills to healthy subjects. Methods: Two groups of male healthy subjects were measured by laser Doppler flow signal. Forty-two subjects in the Liuweidihuangwan experimental group had an average age of (27.8 ± 3.8) years; in the blank experimental group, 28 subjects had a mean age of (27.3 ± 3.4) years. Each measurement experiment contains a basic measurement of 20min and three measurements, of which twice in the day of medication (oral 5g Liuweidihuangwan concentrated powder, with 250mL28 ℃ warm water to take), and the other measured in the first 2 days after taking get on. Results: On the second day after taking medicine, the most obvious average blood flow and pulse wave blood flow were measured at Taixi acupoint. In addition, the spectrum analysis showed that the energy proportion in the frequency band of 0.02 ~ 0.06 Hz was significantly decreased, while in the other Measurement location, there is no significant effect. CONCLUSION: After oral administration of Liuweidihuang Pill, the surface microcirculation blood flow will be redistributed and adjusted. This may be due to different vascular beds and different sympathetic effects of different body surface acupuncture points. This non-invasive and real-time monitoring technology helps to confirm the physiological effects of traditional Chinese medicine and its physiological mechanism.