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目的合成十四、十六、十八酰丙氨酸甲酯,并对其胶凝能力进行考察。方法以丙氨酸甲酯,十四、十六、十八酰氯为原料,合成十四、十六、十八酰丙氨酸甲酯,采用IR、1H-NMR、MS确证其结构,对不同溶剂、不同温度及不同链长的胶凝能力进行研究。结果该类凝胶因子可以在大多数的有机溶剂中形成凝胶,十四、十六、十八酰丙氨酸甲酯在注射用大豆油和中链脂肪酸三甘酯(medium chain triglycerides,MCT)中的最低成胶浓度分别为11.9、7.2、8.5 mg/ml和18.7、12.3、13.4 mg/ml;3种凝胶因子在大豆油中的胶凝焓变分别为74.74、51.70 kJ/mol和61.61 kJ/mol。结论合成得到目标化合物具有较好的胶凝能力,可以作为局部给药的长效药物载体。
Objective To synthesize fourteen, sixteen and octadecanoylalanine methyl esters and investigate their gelation ability. Methods Methylaminomethyl, tetradecyl, hexadecanoyl and octadecanoyl chloride were used as raw materials to synthesize tetradecyl and hexadecanoyl alanylmethyl esters. The structures of the compounds were confirmed by IR, 1H-NMR and MS. Solvent, different temperature and different chain length of the gelling ability of the study. Results This type of gel factor can form gels in most organic solvents. Fourteen, sixteen, octadecanoyl alaninate In the case of injectable soybean oil and medium chain triglycerides (MCT ) Were 11.9, 7.2, 8.5 mg / ml and 18.7, 12.3 and 13.4 mg / ml, respectively. The gelation enthalpies of three kinds of gelling agents in soybean oil were 74.74 and 51.70 kJ / mol, respectively 61.61 kJ / mol. Conclusion The synthesized target compound has good gelling ability and can be used as a long-acting drug carrier for topical administration.