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目的探讨早期应用血必净对重度颅脑外伤患者免疫系统的影响。方法重度颅脑外伤患者60例,随机均分为实验组和对照组,比较治疗前和治疗第4、8天外周血T淋巴细胞亚群CD3+、CD4+、CD8+及单核细胞HLA-DR抗原表达率、免疫球蛋白和补体的变化。结果治疗第4天,实验组CD4+高于对照组,CD8+低于对照组(P<0.05);第8天,实验组HLA-DR、CD3+、CD4+高于对照组,CD8+低于对照组(P<0.05)。治疗第4、8天免疫球蛋白IgA、IgG、IgM均稍高于对照组(P>0.05),补体C3明显低于对照组(P<0.05)。结论常规药物治疗基础上早期加用血必净能提高重度颅脑外伤患者的免疫功能,降低感染率,改善预后。
Objective To investigate the effect of early application of Xuebijing on the immune system in patients with severe craniocerebral trauma. Methods Sixty patients with severe craniocerebral trauma were randomly divided into experimental group and control group. The expression of CD3 +, CD4 +, CD8 + and HLA-DR antigen in peripheral blood mononuclear cells before treatment and on the 4th and 8th day of treatment were compared Rates, changes in immunoglobulins and complement. Results On the 4th day of treatment, the levels of CD4 + in the experimental group were significantly higher than those in the control group, while the levels of CD8 + in the experimental group were lower than those in the control group (P <0.05). On the 8th day, the levels of HLA-DR, CD3 + and CD4 + <0.05). The immunoglobulin IgA, IgG and IgM of the 4th and 8th day of treatment were slightly higher than those of the control group (P> 0.05). The level of complement C3 was significantly lower than that of the control group (P <0.05). Conclusion The conventional treatment with Xuebijing could increase the immune function, reduce the infection rate and improve the prognosis of patients with severe traumatic brain injury.