论文部分内容阅读
SHP-2是蛋白酪氨酸磷酸酶家族中的一员。SHP-2是由PTPN11基因所编码的一种蛋白酪氨酸磷酸酶,它广泛表达于哺乳动物机体的各种组织和细胞中。许多研究表明SHP-2的突变与多种人类肿瘤的发生有密切关系。近年来关于SHP-2在免疫反应过程中的调节作用逐渐受到重视,许多研究证实了其与免疫反应相关的细胞因子及细胞信号转导系统的密
SHP-2 is a member of the protein tyrosine phosphatase family. SHP-2 is a protein tyrosine phosphatase encoded by the PTPN11 gene, which is widely expressed in various tissues and cells of mammalian body. Many studies have shown that SHP-2 mutations are closely related to the occurrence of many human tumors. In recent years, the regulatory role of SHP-2 in the immune response has gradually been taken seriously, and many studies have confirmed its immune response-related cytokines and cellular signal transduction system