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目的 探讨经髂内动脉化疗栓塞晚期前列腺癌的疗效。方法 对 17例晚期前列腺癌行 2 2次介入治疗。其中C1期 3例 ,C2期 5例 ,D1期 6例 ,D2期 3例。所用药物剂量分别是 :卡铂 40 0mg ,丝裂霉素 2 0mg ,表阿霉素 5 0mg ,长春新碱 1mg。栓塞剂选用明胶海绵。结果 17例患者自治疗后第一周 ,所有病人均出现前列腺质地变软和体积缩小 ;第 2～ 3周后体积缩小 3 0～ 5 0 % ;5例术后有神经合并症 ;12例于化疗栓塞 2～ 3周后行尿道电切术。随访 7～ 3 4个月 ,尿流率明显改善 ,残尿量减少或消失。结论 经导管双侧髂内动脉超选择化疗栓塞治疗晚期前列腺癌疗效肯定 ,为综合治疗晚期前列腺癌增加了新的治疗手段 ,特别是对非雄性激素依赖性前列腺癌或内分泌治疗无效者更有意义。
Objective To investigate the effect of endovascular chemotherapy of advanced prostate cancer. Methods Twenty-seven cases of advanced prostate cancer underwent 2 2 interventional procedures. There were 3 cases of C1, 5 cases of C2, 6 cases of D1 and 3 cases of D2. The dosage of the drug used are: carboplatin 40 0mg, mitomycin 20mg, epirubicin 50mg, vincristine 1mg. Embolization agent selection gelatin sponge. RESULTS: In the first week after treatment, all the patients showed prostatosensis and volume reduction in the first week after treatment. The volume decreased by 30% ~ 50% after 2 ~ 3 weeks, neurological complications in 5 cases and 12 cases Chemoembolization 2 to 3 weeks after urethral resection. Followed up for 7 to 34 months, urinary flow rate was significantly improved, residual urine decreased or disappeared. Conclusions Transcatheter arterial superselective chemotherapy and embolization of the internal iliac artery for the treatment of advanced prostate cancer is of certain efficacy, which is a new therapy for the comprehensive treatment of advanced prostate cancer, especially for non-androgen-dependent prostate cancer or ineffective endocrine therapy .