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对某型号国产双极型双路高压运算放大器在不同偏置条件和不同剂量率条件下的电离总剂量效应进行了研究。通过对运算放大器辐照前后的电参数进行测试，计算得到增强因子，分析特殊偏置条件和低剂量率条件对运算放大器电离总剂量效应的影响。试验结果表明，偏置条件不同，运算放大器的电离总剂量效应表现出明显差异性，各管脚短接相对于正常加电工作条件是较恶劣的一种偏置条件。在0.01 rad（si）/s低剂量率条件下，运算放大器表现出潜在的低剂量率增强效应。“,”Total ionizing dose effects on certain type of domestic bipolar dual-way high-voltage operational amplifier under the conditions of different bias and different dose rate is studied. The enhancement factor is obtained by testing the electrical pa-rameters before and after irradiation of operational amplifier. The impact of special bias and low dose rate on total ionizing dose effect of operational amplifier is analysed. The test results show that,under different bias conditions,the total ionizing dose ef-fect of operational amplifier reveals significant difference,Each-pin-short-joint is a more severe bias condition compared with the normal power working conditions. Under the low dose rate condition of 0.01 rad(si)/s,operational amplifiers exhibit a potential enhancement effect of low dose rate.