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目的 :探讨婴儿梅毒的母体情况、婴儿梅毒临床特点、辅助检查及治疗与预后的关系。方法 :对38例婴儿梅毒的临床资料及其母亲孕期情况进行回顾性分析。结果:38例婴儿梅毒中,28例(73.6%)在3个月内发病,临床表现最常见依次为皮疹,贫血,骨骼损害,鼻塞,黄疸等。辅助检查:血常规异常、C反应蛋白增高、肝功能损害等常见,10例(26.3%)四肢长骨X线片提示骨损害。患儿血清快速血浆反应素环状卡片试验滴度≥1∶32者24例(63.1%),母亲孕期予以苄星青霉素正规治疗2例(5.2%)。经水剂青霉素或头孢曲松治疗后,随访26例,均提示治疗有效。结论:婴儿梅毒临床表现多样,诊断需要综合母体孕期、分娩时情况及辅助检查等,经水剂青霉素或头孢曲松治疗后预后好。
Objective: To investigate the maternal condition of infantile syphilis, the clinical features of infantile syphilis, the relationship between auxiliary examination and treatment and prognosis. Methods: The clinical data of 38 infants with syphilis and their mothers during pregnancy were analyzed retrospectively. Results: Among 38 infants with syphilis, 28 cases (73.6%) developed disease within 3 months. The most common clinical manifestations were rash, anemia, bone damage, nasal congestion and jaundice. Auxiliary examination: blood abnormalities, elevated C-reactive protein, liver dysfunction and other common, 10 cases (26.3%) long limb bone X-ray tips bone damage. Twenty-four patients (63.1%) had titers ≥1:32 of titers of cardioprotective plasma cardioprotection in children. Two mothers received amphotericin penicillin regular therapy during pregnancy (5.2%). After the water penicillin or ceftriaxone treatment, follow-up of 26 cases were prompted to be effective. Conclusion: There are many clinical manifestations of syphilis in infants. The diagnosis needs comprehensive maternal pregnancy, childbirth and auxiliary examination. The prognosis is good after penicillin or ceftriaxone treatment.