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目的研究有机氯农药暴露与女性乳腺癌患病风险。方法运用病例对照研究,留取患者血清标本5ml和乳腺脂肪组织标本10g,气相色谱仪检测血清和乳腺脂肪组织中有机氯农药暴露水平。结果患者的居住地在病例组和对照组之间差异有统计学意义(P=0.03),将居住地分层。城市和农村患者,血清中β-HCH和PCTA暴露与乳腺癌的发生正相关(P﹤0.01);脂肪组织中β-HCH、PCTA和PP’-DDE暴露与乳腺癌的发生正相关(P﹤0.01)。绝经前组,血清中PCTA暴露在城市患者中与乳腺癌发生正相关(P=0.03),脂肪组织中PCTA和PP’-DDE暴露在城市和农村患者中均与乳腺癌发生正相关(P﹤0.05);绝经后组,血清和脂肪组织中PCTA暴露在城市和农村患者中均与乳腺癌发生正相关(P﹤0.05),脂肪组织中β-HCH暴露在城市患者、PP’-DDE暴露在农村患者中均与乳腺癌发生正相关(P﹤0.05)。有机氯农药暴露增加乳腺癌的患病风险,血清和脂肪组织中,OR值均大于2。结论有机氯农药暴露可能与乳腺癌发生有关,可能与绝经前后乳腺癌发生均有关。
Objective To study the risk of organochlorine pesticide exposure and female breast cancer. METHODS: A case-control study was conducted. 5 ml of serum samples and 10 g of adipose tissue specimens were collected. Gas chromatography was used to detect the levels of organochlorine pesticides in serum and breast adipose tissue. Results There was a statistically significant difference in the patient’s place of residence between the case group and the control group (P=0.03), and the place of residence was stratified. In urban and rural patients, serum β-HCH and PCTA exposure was positively correlated with breast cancer (P<0.01); β-HCH, PCTA, and PP′-DDE exposures were positively correlated with breast cancer (P< 0.01). In the premenopausal group, serum PCTA exposure was positively correlated with breast cancer in urban patients (P = 0.03), and PCTA and PP’-DDE exposure in adipose tissue were positively correlated with breast cancer in urban and rural patients (P < 0.05); In the postmenopausal group, both PCNA exposure in serum and adipose tissue was positively correlated with breast cancer in both urban and rural patients (P<0.05). β-HCH in adipose tissue was exposed in urban patients and PP’-DDE was exposed. All patients in rural areas were positively correlated with breast cancer (P<0.05). Exposure of organochlorine pesticides increased the risk of breast cancer, with OR values greater than 2 in serum and adipose tissue. Conclusion The exposure of organochlorine pesticides may be related to the occurrence of breast cancer, and may be related to the occurrence of breast cancer before and after menopause.