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应用重组白细胞介素－６（ｒＩＬ－６）及白细胞介素－６单抗（ＩＬ－６ＭｃＡｂ）分别处理脑胶质瘤细胞株ＳＨＧ－４４及４例脑胶质瘤患者体外培养的人脑胶质瘤细胞。结果显示，ｒＩＬ－６能刺激ＳＨＧ－４４细胞及人脑胶质瘤细胞的增殖，且均呈剂量依赖关系。表明人脑胶质瘤中亦存在白细胞介素－６（ＩＬ－６）自分泌环路，这种自分泌环路的存在可能参与维持脑胶质瘤的恶性增殖。
The human glial cells were cultured in vitro with recombinant human interleukin-6 (IL-6) and interleukin-6 (IL-6McAb) in SHG-44 glioma cell line and in 4 glioma patients Tumor cells. The results showed that rIL-6 could stimulate the proliferation of SHG-44 cells and human glioma cells in a dose-dependent manner. That human glioma also exists in the interleukin-6 (IL-6) autocrine loop, the existence of this autocrine loop may be involved in the maintenance of glioma malignant proliferation.