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生命早期的不良经历一直潜在影响着人类的健康。童年期不良经历通过对神经内分泌功能的改变影响着功体的生理功能与内环境稳定,增加了心血管疾病、糖尿病、癌症、神经退行性疾病、关节炎等的患病风险。Levine等的研究评估了114名51~95岁的健康退休老人童年期和成年期不良经历对晚年促炎症基因表达的影响,采用最小二乘法回归模型(OLS regression models)分析童年期创伤、童年期社会经济地位、童年期健康状况、成人期创伤、成人期低社会经济地位与老年期综合促炎症基因表达水平的关系,结果显示,仅童年期创伤与老年期炎症基因转录增强有关。笔
The bad experiences of early life have been potentially affecting human health. Childhood adverse experiences affect the physiological function of the body and the stability of the internal environment through changes in neuroendocrine function, and increase the prevalence of cardiovascular diseases, diabetes, cancer, neurodegenerative diseases and arthritis. A study by Levine et al. Evaluated the effects of childhood and adulthood ill health experiences among 114 elderly retired people aged 51-95 on proinflammatory gene expression in later life. OLS regression models were used to analyze childhood childhood trauma and childhood Socioeconomic status, childhood health status, adult trauma, adulthood low socioeconomic status and senile comprehensive pro-inflammatory gene expression levels, the results showed that only childhood trauma and senile inflammatory gene transcription is enhanced. pen