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目的 探讨T1 T2 鼻咽癌常规分割放疗中疗程和放疗间断时相对鼻咽癌局部控制率的影响。方法 88例T1 T2 鼻咽癌患者于 1989年 1月 - 1990年 12月住院首次放疗 ,鼻咽原发灶全部采用6 0 Co外照射 ,采用常规分割 :1.7～ 2Gy 次 ,总量 65 .3 4～ 82 .75Gy 3 3～ 4 7次 4 7～ 86d ,应用kaplan Meier计算局控率、用Log rank行差异性检验。结果 疗程 <5 6d、≥ 5 6d的 5年鼻咽局控率分别为 92 .3 9%、72 .80 % ,有显著差异 (P =0 .0 14 6) ,而放疗中断发生在放疗疗程的时相对局控率无明显影响 (P >0 .0 5 )。结论 T1 T2 鼻咽癌常规分割放疗中疗程延长将降低局控率 ,且不论放疗间断发生在放疗的时相 ,因此在临床实践中注意避免不必要的放疗疗程的延长。
Objective To investigate the effect of local radiotherapy and radiotherapy on the local control of nasopharyngeal carcinoma in patients with T1 T2 nasopharyngeal carcinoma. Methods Eighty-eight patients with T1 T2 nasopharyngeal carcinoma were admitted to hospital for the first time between January 1989 and December 1990. The primary tumors of the nasopharynx were all irradiated with 60Co, and the routine segmentation was performed from 1.7 to 2 Gy for a total of 65.3 4 ~ 82 .75Gy 3 3 ~ 4 7 times 4 7 ~ 86d, the use of kaplan Meier calculation of local control rate, Log rank difference test. Results The 5-year nasopharyngeal control rates of 5 days and 5 days were 92.39% and 72.80%, respectively (P = 0.014 6). The interruption of radiotherapy occurred during radiotherapy When compared with the rate of local control had no significant effect (P> 0.05). Conclusions The prolonged course of treatment in routinely divided radiotherapy of T1 T2 nasopharyngeal carcinoma will reduce the rate of local control. Regardless of radiotherapy interruption occurs in the radiotherapy phase, so in clinical practice to avoid unnecessary radiation therapy to extend the course.