醋酸棉酚具有抗生育作用,已作为男用避孕药在临床试用,效果肯定。我们根据醋酸棉酚结构中具有酚羟基的性质,在非水介质中直接用甲醇钠溶液进行滴定,方法简便,终点明确,杂质不干扰。此法曾于1977年全国棉酚质量会上报告并建议作为醋酸棉酚含量测定的方法。方法:精密称取醋酸棉酚25mg(或醋酸棉酚片20片,精密称重,计算平均片重,研细,称取相当 Gossypol acetate has anti-fertility effects, has been used as a male contraceptive in clinical trials, the effect is affirmed. According to the nature of phenolic hydroxyl group in gossypol acetic acid structure, titration with sodium methoxide solution in non-aqueous medium is simple, the method is simple, the end point is clear, and the impurities do not interfere. This method was reported in 1977, the national gossypol quality and recommended as gossypol acetate content determination method. Methods: Precision weighed gossypol acetate 25mg (or cotton gossamer acetate tablets 20, precision weighing, calculate the average weight, research fine, weighed quite