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目的:探究腹腔热灌注化疗对胃癌患者免疫功能及临床疗效的影响。方法:根据治疗方案不同将66例胃癌术后患者分为研究组(36例)和对照组(30例),分别给予腹腔热灌注化疗和常规静脉化疗,比较两组患者免疫功能改善情况及临床治疗效果。结果:研究组治疗后T细胞亚群指标均得到改善,治疗总有效率(86.1%)高于对照组(66.7%),1年内腹腔内局部复发率(13.9%)低于对照组(23.3%),比较差异显著(P<0.05);两组毒副反应发生情况及远处转移情况比较,差异并不显著(P>0.05)。结论:腹腔热灌注化疗毒副反应少,能够增强胃癌患者术后免疫功能,提高其生存质量。
Objective: To investigate the effect of intraperitoneal hyperthermic perfusion chemotherapy on immune function and clinical efficacy in patients with gastric cancer. Methods: Sixty-six patients with gastric cancer were divided into study group (36 cases) and control group (30 cases) according to different treatment plans. The patients were given intraperitoneal hyperthermic chemotherapy and conventional intravenous chemotherapy respectively. The improvement of immune function and clinical treatment effect. Results: The T lymphocyte subsets in the study group were improved after treatment. The total effective rate (86.1%) was higher in the study group than that in the control group (66.7%). The intra-abdominal recurrence rate (13.9%) in one year was lower than that in the control group (23.3% ) (P <0.05). There was no significant difference between the two groups in the incidence of side effects and distant metastasis (P> 0.05). Conclusion: Intraperitoneal hyperthermic perfusion chemotherapy has few side effects, which can enhance postoperative immune function and improve quality of life of gastric cancer patients.