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目的:对唑来膦酸治疗恶性肿瘤骨转移引起的疼痛进行药物经济学评价。方法:根据随机、双盲双模拟临床试验获得的疗效结论,结合成本信息,以帕米膦酸二钠为对照,采用成本-效果分析模型进行药物经济学评价。结果:唑来膦酸的成本-效果比为28.54,而帕米膦酸二钠的成本效果比为34.58。结论:与帕米膦酸二钠相比,唑来膦酸治疗恶性肿瘤骨转移引起的疼痛具有更优的成本-效果,可以为临床节约卫生资源。
OBJECTIVE: To evaluate the pharmacokinetics of zoledronic acid in the treatment of pain caused by bone metastases of malignant tumors. Methods: Based on the results of the randomized, double-blind, double-dummy clinical trial and the cost information, the pamidronate disodium was used as a control and the cost-effectiveness analysis model was used to evaluate the pharmacoeconomics. Results: The cost-effect ratio of zoledronic acid was 28.54, while the cost-effectiveness ratio of pamidronate was 34.58. Conclusion: Compared with pamidronate disodium, zoledronic acid in the treatment of malignant bone metastases caused by pain has a better cost-effectiveness, can be clinically effective for the conservation of health resources.