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BACKGROUND:?Living? donor? liver? transplantation? (LDLT)?has?been?widely?accepted?over?the?past?decade,?and?hepatic?dysfunction?often?occurs?in?the?donor?in?the?early?stage?after?liver?donation.?The?present?study?aimed?to?evaluate?the?effect?of?intra-operative?cholangiography?(IOC)?and?parenchymal?resection?on?liver?function?of?donors?in?LDLT,?and?to?assess?the?role?of?IOC?in?inlfuencing?the?biliary?complications?and?improving?the?overall?outcome. METHODS:?Data?from?40?patients?who?had?donated?their?right?lobes?for?LDLT?were?analyzed.?Total?bilirubin?(TB),?alanine?aminotransferase? (ALT),? aspartate? aminotransferase? (AST),?alkaline?phosphatase?(ALP)?and?γ-glutamyl?transpeptidase?(GGT)?at?different?time?points?were?compared,?and?the?follow-up?data?and?the?biliary?complications?were?also?analyzed. RESULTS:?The?ALT?and?AST?values?were?signiifcantly?increased?after? IOC? (P0.05).?The?biochemical?changes?caused?by?IOC?or?parenchymal?resection?were?not?correlated?with?the?degree?of?post-operative?liver?injury?or?the?recovery?of?liver?function.?The?liver?functions?of?the?donors?after?operation?were?stable,?and?none?of?the?donors?suffered?from?biliary?stenosis?or?leakage?during?the?follow-up. CONCLUSIONS:?IOC?and?parenchymal?resection?may?induce?a?transient?increase?in?liver?enzymes?of?donors?in?LDLT,?but?do?not?affect?the?recovery?of?liver?function?after?operation.?Moreover,?the?routine?IOC?is?helpful?to?clarify?the?division?line?of?the?hepatic?duct,?thus?reducing?the?biliary?complication?rate.