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本研究运用动物实验观察了不同剂量三硝基甲苯（ＴＮＴ）处理大鼠，对血清睾酮（Ｔ）水平及睾丸Ｌｅｙｄｉｇ细胞３β－羟基类固醇脱氢酶（３β－ＨＳＤ）活性影响以及睾丸病理学改变。结果显示，ＴＮＴ２００ｍｇ／ｋｇ处理组大鼠血清Ｔ含量显著低于对照组（Ｐ＜０．０５），而ＴＮＴ１００和２００ｍｇ／ｋｇ处理组大鼠睾丸Ｌｅｙｄｉｎｇ细胞３β－ＨＳＤ活性显著低于对照组（Ｐ＜０．０５）。组织病理学检查结果表明，ＴＮＴ１００和２００ｍｇ／ｋｇ处理组大鼠睾丸Ｌｅｇｄｉｇ细胞结构基本正常，但可引起生精上皮结构改变。
In this study, we observed the effects of different doses of TNT on serum testosterone (T) levels and 3β-hydroxysteroid dehydrogenase (3β-HSD) activity in testis Leydig cells and the pathological changes of testis . The results showed that the serum T content of rats treated with TNT200mg / kg was significantly lower than that of the control (P <0.05), while the activity of 3β-HSD in testis Leyding cells was significantly lower than that of the control (P <0.05). The results of histopathological examination showed that the structure of Legdig cells in testis of TNT100 and 200 mg / kg groups was normal, but the structure of seminiferous epithelium was changed.