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目的观察谷氨酰胺联合亚胺培南治疗重症急性胰腺炎合并感染患者的临床效果。方法选取医院收治的102例重症急性胰腺炎合并感染患者作为研究对象,按照入院时间将其分为对照组和观察组,每组51例。对照组给予亚胺培南治疗,观察组给予亚胺培南+谷氨酰胺治疗,对2种治疗策略的效果进行分析和比较。结果治疗后,2组白细胞计数、C反应蛋白指标较治疗前均降低,血小板计数较治疗前升高,且观察组升高、降低的幅度大于对照组(P<0.05或P<0.01);观察组治疗总有效为86.27%,明显高于对照组的58.82%(P<0.01)。结论重症急性胰腺炎合并感染患者给予亚胺培南联合谷氨酰胺治疗可提高治疗总有效率,还可改善各项临床指标,具有显著临床应用价值。
Objective To observe the clinical effect of glutamine combined with imipenem in the treatment of patients with severe acute pancreatitis complicated with infection. Methods Totally 102 patients with severe acute pancreatitis who were admitted to hospital were enrolled in this study. According to their admission time, they were divided into control group and observation group, with 51 cases in each group. The control group was given imipenem, while the observation group was given imipenem plus glutamine. The effects of the two treatment strategies were analyzed and compared. Results After treatment, the white blood cell count and C-reactive protein index of the two groups were lower than those before treatment, and the platelet count was higher than that before treatment. The observation group was higher than the control group (P <0.05 or P <0.01) The total effective rate was 86.27% in treatment group, which was significantly higher than that in control group (58.82%, P <0.01). Conclusions Imipenem combined with glutamine treatment in patients with severe acute pancreatitis infection can improve the total effective rate of treatment, and can improve various clinical indexes, which has significant clinical value.