正常妊娠的维持有赖于多种因素的参与,如母-胎免疫耐受、足量的激素支持等,近年来的研究显示,半乳凝集素-1可以介导母-胎免疫耐受,并通过与黄体酮的协同作用参与正常妊娠的维持。而且,半乳凝集素-1与反复自发性流产(RSA)、子痫前期和妊娠期糖尿病的发生均有关联。对半乳凝集素-1的研究可以帮助我们更加深入地了解正常妊娠与异常妊娠,从而为妊娠相关疾病的诊断及治疗提供新的研究思路。 The maintenance of normal pregnancy depends on many factors involved, such as mother-child immune tolerance, adequate hormone support, recent studies have shown that galectin-1 can mediate the mother-child immune tolerance and Through the synergistic effect with progesterone involved in the maintenance of normal pregnancy. Moreover, galectin-1 is associated with recurrent spontaneous abortion (RSA), preeclampsia and gestational diabetes mellitus. The study of galectin-1 can help us to understand more about normal pregnancy and abnormal pregnancy, so as to provide new research ideas for the diagnosis and treatment of pregnancy-related diseases.