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维生素B_(12)在机体内以氰钴胺(CN-B_(12))、羟钴胺(OH-B_(12))、钴酰胺(DBCC)、甲钴胺(CH_3-B_(12))的形式存在,只有DBCC与甲钴胺在体内有辅酶活性,尤其是甲钴胺参与转甲基反应,促进体内核酸、蛋白合成与磷脂合成等,因此,男性不孕症与维生素B_(12)的关系受到了重视。一、维生素B_(12)缺乏时对雄性生殖器官的影响及给与维生素B_(12)的效果维生素B_(12)缺乏实验主要是对血象与代谢等进行观察,关于各器官变化的报告不多,尤其对雄性生殖器官影响的研究报道很少。梅村给大鼠以缺乏维生素B_(12)的饮食达115日,从组织学上研究全身各器官,发现
Vitamin B 12 in the body with cyanocobalamin (CN-B 12), hydroxocobalamin (OH-B 12), cobalt amide (DBCC), mecobalamin (CH 3 -B 12) , Only DBCC and mecobalamin have coenzyme activity in vivo, especially methylcobalamin is involved in transmethylation reaction to promote nucleic acid, protein synthesis and phospholipid synthesis in vivo. Therefore, male infertility and vitamin B_ (12) The relationship has been taken seriously. First, the lack of vitamin B_ (12) on the male reproductive organs and to give the effect of vitamin B_ (12) Vitamin B_ (12) lack of experiments mainly on the blood and metabolism were observed, on the report of changes in various organs There are few reports on the effects of male genital organs. Umemura to rats in the absence of vitamin B_ (12) diet for 115 days, from the histological study of various organs and found that