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目的 分析急诊肿瘤晚期感染患者的病原菌分布及炎性指标变化的意义,为提高临床诊断治疗效果提供客观依据。方法 选取2015年1月-2016年12月医院急诊收治的89例晚期肿瘤合并感染患者作为研究对象,对患者感染部位进行观察和分析,对患者感染分泌物样本中的病原菌分布及耐药性进行检测和分析,对患者入院时血样本中炎症标志物水平进行检测和比较。结果 89例感染患者共检出94株病原菌,以革兰阴性菌为主,共53株占56.4%;主要革兰阴性菌对环丙沙星、磺胺甲噁唑/甲氧苄啶的耐药率较高,对阿米卡星较为敏感;革兰阴性菌感染患者的血浆降钙素原(PCT)、C-反应蛋白(CRP)、脂多糖(LPS)水平均高于革兰阳性菌感染患者(P<0.05)。结论 急诊肿瘤晚期合并感染患者的感染部位、病原菌分布及耐药性、炎症指标变化均具有一定的特征,临床医生应给予高度的重视、密切的监测及有效的诊治,以提高感染的诊治效果,改善患者的预后。
Objective To analyze the distribution of pathogenic bacteria and the significance of inflammatory markers in patients with advanced stage of advanced cancer and provide objective basis for improving the clinical diagnosis and treatment. Methods Eighty-nine patients with advanced cancer co-infection who were hospitalized from January 2015 to December 2016 in our hospital were selected as the research object. The infected sites were observed and analyzed. The distribution and drug resistance of the pathogens in the patients’ Detection and analysis, the level of inflammatory markers in blood samples of patients admitted to hospital were detected and compared. Results A total of 94 pathogenic bacteria were detected in 89 infected patients, mainly gram-negative bacteria, accounting for 56.4% of 53 strains. The major Gram-negative bacteria were resistant to ciprofloxacin and sulfamethoxazole / trimethoprim Higher rate, more sensitive to amikacin; Gram-negative bacterial infections in patients with plasma procalcitonin (PCT), C-reactive protein (CRP), lipopolysaccharide (LPS) Patients (P <0.05). Conclusions The infection site, distribution of pathogens, drug resistance and index of inflammation in emergency patients with advanced CT have certain characteristics. Clinicians should pay high attention, close monitoring and effective diagnosis and treatment to improve the diagnosis and treatment of infection. Improve patient’s prognosis.