微生物转化已经作为一种方法,应用于定量地产生比抗肿瘤生物碱山油柑碱活性强的代谢产物。在小规模发酵中,为了筛选山油柑碱转化为代谢产物的能力,试验了40多种微生物。在培养基中找到了累积数神山油柑碱衍生物的10种培养方法。在一个带搅伴的发酵器中,Cunninghamella echi-milata 可将山油柑碱转化为酚性的代谢产物9-羟 Microbial transformation has been used as a method for quantitatively generating metabolites that are more potent than the antineoplastic alkaloid oleanine. In small-scale fermentations, more than 40 microorganisms were tested in order to screen the ability of coryl to convert to metabolites. Ten culture methods of cumulated kumquat derivatives were found in the medium. In a fermenter with agitation, Cunninghamella echi-milata converts kaempferol to the phenolic metabolite 9-hydroxy