在炎症反应导致全身性炎症反应 (SIRS)或多器官功能不全 (MODS)的过程中 ,丝裂原活化蛋白激酶(MAPK)通路可能起了重要作用。因而 ,研究MAPK的激活状态可能成为识别处于SIRS/MODS高危状态下病人的一个方法。另外 ,对该通路的恰当调控可以改善病人的预后。然而 ,MAPK家族只是这个复杂的相互作用的网络中的一部分 ,不加区别地抑制或激活其中某一单个部分可能导致难以预料的反应 Mitogen-activated protein kinase (MAPK) pathways may play an important role in the inflammatory response leading to systemic inflammatory response (SIRS) or multiple organ dysfunction (MODS). Thus, studying the activation status of MAPK may be one way to identify patients at high risk of SIRS / MODS. In addition, proper regulation of this pathway can improve the patient’s prognosis. However, the MAPK family is only part of this complex, interacting network and indiscriminate suppression or activation of one single part of it can cause unpredictable responses