Vig曾指出:着丝粒过早分离(PCD)可产生非整倍体细胞,因为PCD的着丝粒不能为纺锤丝相接,而导致不分离。本文报道的家族中的几个人均带有PCD频率较高的细胞,并有生育力低下。先证者曾五次自然流产,现有健康子女两个;其母也曾二次流产,仅有该女患一人。作者分析了经用和不用秋水仙素培养的先证者外周血淋巴细胞和皮肤成纤维细胞染色体组型,同时也对其父亲、母亲及其丈夫和儿子、女儿的外周血淋巴细胞染色体进行了分析,培养条件也分加 Vig has pointed out that premature centromere isolation (PCD) produces aneuploid cells because the centromere of PCD can not interface with the spindle, resulting in non-segregation. Several of the families reported in this paper have cells with higher PCD frequency and have poor fertility. The proband had five spontaneous abortions and had two healthy children; her mother had had a second abortion and only one of the women was suffering from it. The authors analyzed the chromosomal patterns of peripheral blood lymphocytes and skin fibroblasts from probands cultured with and without colchicine, as well as the peripheral blood lymphocyte chromosomes of their father, mother, and her husband and sons and daughters Analysis, culture conditions are also divided