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目的探讨染色体数目、结构和多态性异常与不孕不育临床表现的关系。方法按照常规G显带方法制备外周血淋巴细胞染色体,并对其核型进行数目和结构的分析,必要的做C显带和Y染色体微缺失。结果 7658例不孕不育病例中251染色体核型异常,异常率为3.28%,其中数目异常93例,结构异常158例,比例分别为1.22%、2.06%,染色体多态性630例,比例为8.23%。结论细胞学遗传学对于不孕不育患者在优生优育中具有指导意义。
Objective To explore the relationship between chromosome number, structure and polymorphism and clinical manifestations of infertility. Methods Chromosomes of peripheral blood lymphocytes were prepared according to the conventional method of G - banding. The number and structure of karyotypes were analyzed. C - banding and Y chromosome microdeletions were necessary. Results The chromosome aberration of 251 chromosome in 7658 cases of infertility was abnormal, the rate of abnormality was 3.28%, of which 93 cases were abnormal in number and 158 cases were abnormal in structure, the proportions were 1.22% and 2.06% respectively, and the chromosome polymorphism was 630 cases 8.23%. Conclusion Cytogenetics has guiding significance in prenatal and postnatal care for patients with infertility.