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目的：研究缓症链球菌中毒性休克综合征（TSS）的临床特征及致病机理。方法：对178例重症类猩红热进行临床观察，并对咽拭子培养菌株应用新西兰兔作动物实验，进行毒素分离鉴定。结果：本组病例临床特征为突起畏寒、高热，猩红热样皮疹，不同程度的休克，多脏器功能受损。大多数病人咽拭子培养有α-溶血的缓症链球菌生长，此菌株产生一种分子量为34KD新的致热性外毒素。结论：缓症链球菌可致中毒性休克综合征。
Objective: To study the clinical characteristics and pathogenesis of Streptococcus mutans toxic shock syndrome (TSS). Methods: A total of 178 severe cases of scarlet fever were observed, and New Zealand rabbits were used as experimental animals for throat swab culture. Results: The clinical features of this group of patients with sudden chills, fever, scarlet fever-like rash, varying degrees of shock, multiple organ damage. Most patients have throat swabs with alpha-hemolysis Streptococcus sobrinus, which produces a new pyrogenic exotoxin with a molecular weight of 34 kD. Conclusion: Streptococcus mutans can cause toxic shock syndrome.