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本文报告用我校药物研究室制备的前列腺素E_1(PGE_1)辅助治疗22例克山病心功能不全(Ⅲ～Ⅳ级),取得一定疗效。PGE_1静脉滴注,剂量200～600μg/day(按不同年龄和体重)稀释于10％葡萄糖200～400ml内,约4/小时滴完。平均剂量:儿童0.05～0.08μg/kg/min,成人0.03～0.06μg/kg/min,每日1次。疗程最短3日,最长20日,平均8日。监测血压、心率、肝脏大小。治疗前一天、首次滴注后的当日下午和疗程结束时用多导生理记录仪同步描记心电图、心音图、颈总动脉波等。按治疗前、当日、疗后自身比较的成对数据计算差值。PGE_1治疗后精神好转7例,食欲增加11例,尿量增多7例。亚急克和慢克的收缩压(以下均为均值)分别由84降到78和由87降到86;舒张压分别由56降到50和由62降到56。心率分别由111减到105次和由91减到89次。肝肿大剑突下分别由3.5缩到3.1cm(P>0.05)和由5.6缩到4.3cm(p<0.05);右季肋下分别由1.8缩到1.2cm(p>0.05)和由3.4缩到2.3cm(p<0.01),表明肝肿大有回缩,以慢克较明显。STI测定:亚急克病例ICT疗后比疗前缩短5.7ms(P<0.05),其余改变不大。儿
This report reports the use of prostaglandin E_1 (PGE_1) prepared by our institute for the treatment of 22 cases of Keshan’s heart failure (Ⅲ ~ Ⅳ grade), and achieved a certain effect. PGE_1 intravenous infusion, the dose of 200 ~ 600μg / day (by age and weight) diluted in 10% glucose 200 ~ 400ml, about 4 / hour drops finished. The average dose: 0.05 ~ 0.08μg / kg / min for children, 0.03 ~ 0.06μg / kg / min for adults, once daily. The shortest course of 3 days, up to 20 days, an average of 8 days. Monitor blood pressure, heart rate, liver size. The day before treatment, the afternoon after the first instillation and at the end of the treatment, a multichannel physiologic logger was used to synchronously record the ECG, phonocardiogram, common carotid artery wave and so on. According to the treatment before, on the same day, after treatment comparison of the paired data to calculate the difference. PGE_1 improved after treatment, 7 patients improved appetite in 11 cases, increased urine output in 7 cases. The systolic and mean systolic blood pressures (all mean values below) were decreased from 84 to 78 and from 87 to 86, respectively; diastolic blood pressure decreased from 56 to 50 and from 62 to 56, respectively. The heart rate decreased from 111 to 105 and from 91 to 89, respectively. (P> 0.05) and reduced from 5.6 to 4.3 cm (P <0.05), respectively; from right lower rib to 1.8 cm (p> 0.05) and from 3.4 Shrink to 2.3cm (p <0.01), indicating that hepatomegaly retracted to more obvious grams. STI determination: After acupuncture treatment, the shortening of 5.7 ms (P <0.05) in ICT patients after treatment was less than that before treatment. child