目的:研究芹菜素对高脂高盐所致高血压大鼠降压及心脏的保护作用。方法:通过高脂高盐饲料加5%盐水连续喂养8周制备高血压模型大鼠,选取60只并按照血压水平随机分为5组:高血压模型组、芹菜素(20、40和80 mg/kg)治疗组和卡托普利(25mg/kg)对照组,每组12只,另取12同龄正常饲养大鼠作为正常对照组;灌胃给药4周,高血压模型组和正常组均给予等体积的生理盐水。给药前及给药治疗4周后测定各组大鼠收缩压(SBP)和舒张压(DBP);治疗4周后,分别测定各组大鼠血清中血管紧张素II(Ang II)水平,心肌增值系数(MPI)及心脏系数(CWI);测定血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)水平,测定血清中谷草转氨酶(AST)、磷酸肌酸酶(CPK)、乳酸脱氢酶(LDH)活性;测定心肌组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)的活性和丙二醛(MDA)的含量。结果:与高血压模型组比,芹菜素(40和80mg/kg)治疗组大鼠血清中Ang II水平显著降低,SBP均显著降低,芹菜素80mg/kg治疗组DBP显著降低;芹菜素(40和80mg/kg)治疗组大鼠血清中TC、TG含量水平显著降低,AST、CPK、LDH活性显著降低;心肌组织中SOD、CAT活性显著升高、MDA含量显著降低。芹菜素80mg/kg治疗组大鼠MPI和CWI显著降低;血清中LDL-C水平显著降低、HDL-C水平显著升高;心肌组织中GSH-Px活性显著升高。结论:芹菜素降低高脂高盐所致高血压大鼠血压并有保护心脏的作用,其作用机制可能与芹菜素能够有效降低高脂高盐所致高血压大鼠Ang II水平、降低血脂、改善抗氧化酶活性、抑制氧化应激损伤有关。 Objective: To study the effect of apigenin on blood pressure and heart protection in hypertensive rats induced by high fat and high salt. Methods: Hypertensive rats were prepared by continuous feeding of high-fat and high-salt diet plus 5% saline for 8 weeks. Sixty selected rats were randomly divided into five groups according to their blood pressure: hypertension model group, apigenin (20, 40 and 80 mg / kg) and captopril (25mg / kg) control group, 12 rats in each group, and 12 rats of normal age were used as normal control group. After oral administration for 4 weeks, model group and normal group Equal volumes of saline were given. Before treatment and after 4 weeks of treatment, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of rats in each group were measured. After 4 weeks of treatment, the levels of serum angiotensin II (Ang II) (MPI) and cardiac coefficient (CWI). The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL- Serum aspartate aminotransferase (AST), creatine phospholase (CPK) and lactate dehydrogenase (LDH) activity were measured. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px ), Catalase (CAT) activity and malondialdehyde (MDA) content. Results: Compared with the model group, the levels of Ang II in the serum of the rats treated with apigenin (40 and 80 mg / kg) were significantly decreased, while the SBP decreased significantly. The DBP of the apigenin 80 mg / kg treatment group was significantly reduced. And 80mg / kg), the levels of TC and TG in the serum of the rats in the treatment group were significantly decreased, while the activities of AST, CPK and LDH were significantly decreased. The activities of SOD and CAT were significantly increased and the content of MDA was significantly decreased in the myocardium. The MPI and CWI in the apigenin 80 mg / kg treatment group were significantly decreased; the levels of LDL-C and HDL-C in serum were significantly decreased; the activity of GSH-Px in myocardium was significantly increased. Conclusions: Apigenin can reduce the blood pressure and protect the heart of hypertensive rats induced by high fat and high salt. Its mechanism may be that apigenin can effectively reduce the level of Ang II in hypertensive rats induced by high fat and high salt, Improve antioxidant enzyme activity and inhibit oxidative stress injury.