Research on the propagation of elastic waves in piezoelectric nanostructures is very limited. The frequency dispersion of Love waves in layered piezoelectric nanostructures has not yet been reported when surface effects are taken into account. Based on the surface elasticity theory, the propagation of Love waves with surface effects in a structure consisting of a nanosized piezoelectric film and a semi-infinite elastic substrate is investigated focusing on the frequency dispersion curves of different modes. The results show that under the electrically-open conditions, surface effects give rise to the dependence of Love wave dispersion on the film thickness when the thickness of the piezoelectric film reduces to nanometers. For a given wave frequency, phase velocity of Love waves in all dispersion modes exhibit obvious toward shift as the film thickness decreases or the surface parameters increase. Moreover, there may exist a cut-off frequency in the first mode dispersion below which Love waves will be evanescent in the structure due to surface effects. The cut-off frequency depends on the film thickness, the surface parameters and the bulk material properties. Research on the propagation of elastic waves in piezoelectric nanostructures is very limited. The frequency dispersion of Love waves in layered piezoelectric nanostructures has not yet been reported when surface effects are taken into account. Based on the surface elasticity theory, the propagation of Love waves with surface effects in a structure consisting of a nanosized piezoelectric film and a semi-infinite elastic substrate is investigated focusing on the frequency dispersion curves of different modes. The results show that under the electrically-open conditions, surface effects give rise to the dependence of Love wave dispersion on the film thickness when the thickness of the piezoelectric film reduces to nanometers. Moreover, there are some wave frequencies that phase velocity of Love waves in all dispersion modes exhibit exhibit toward shift as the film thickness decreases or the surface parameters increase. may exist a cut-off frequency in the first mode dispersion below which Lo ve waves will be evanescent in the structure due to surface effects. The cut-off frequency depends on the film thickness, the surface parameters and the bulk material properties.