以邻硝基甲苯和邻氯苯甲醛为起始原料,经醇醛缩合、脱水、还原、环合得关键中间体亚氨基芪,再与三光气酰氯化、氨化得卡马西平,总收率31%。起始原料价廉易得,合成路线短,不涉及溴化物,有望成为工业化路线。 To o-nitrotoluene and o-chlorobenzaldehyde as the starting material, the aldol condensation, dehydration, reduction, cyclization in the key intermediates iminostilbene, and then with three phosgene chloride, ammoniated carbamazepine, total revenue Rate of 31%. The starting materials are cheap and easy to obtain, the synthesis route is short and no bromide is involved, which is expected to become an industrialized route.