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采用回顾性分析的方法,分析了我院2013年1~12月3916例孕9~13+w孕妇血清产前检查的资料,通过分析其游离β-HCG和和妊娠相关血浆蛋白A的水平(对于孕10~13w结合超声NT值),评估患者的DS风险情况。结果 3916例孕妇中,筛查DS高危150例,筛查阳性率为3.83%(150/3916);18三体综合征高危4例,筛查阳性率为0.15%(6/3916);不同年龄的高风险分组中,大于或等于35岁组DS风险率高于其他组,差异有统计学意义(P<0.05);17~25岁年龄组DS风险率低于其他组,差异有统计学意义(P<0.05)。孕早期进行DS筛查有利于发现异常胎儿,为产前诊断提供重要信息,是降低出生缺陷率的有效手段。
The retrospective analysis was used to analyze the data of prenatal examination of 3916 pregnant women with 9 ~ 13 + w pregnancies from January 2013 to December 2013 in our hospital. The levels of free β-HCG and pregnancy-related plasma protein A ( For pregnant 10 ~ 13w combined with ultrasound NT value), to assess the patient’s risk of DS. Results Among 3916 pregnant women, screening high risk of DS was 150 cases, the positive rate of screening was 3.83% (150/3916); the high risk of trisomy 18 was 4 cases, the positive rate of screening was 0.15% (6/3916); different age (P <0.05). The risk of DS in 17-25 years old group was lower than other groups, the difference was statistically significant (P <0.05). DS screening in early pregnancy is conducive to the discovery of abnormal fetuses, provide important information for prenatal diagnosis, is an effective means to reduce the birth defect rate.