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目的探讨甘精胰岛素治疗老年2型糖尿病的临床疗效及安全性。方法选取新疆乌鲁木齐市友谊医院2014—2016年收治的2型糖尿病患者100例,按入院顺序分为对照组和治疗组,各50例。对照组患者采用低精蛋白重组人胰岛素治疗,治疗组患者给予甘精胰岛素治疗,两组患者均持续治疗14 d。比较两组患者治疗前后血糖指标(空腹血糖、空腹C肽、餐后2 h血糖、糖化血红蛋白)、血糖达标时间及治疗费用,并观察患者不良反应发生情况。结果治疗前,两组患者空腹血糖、空腹C肽、餐后2 h血糖、糖化血红蛋白比较,差异无统计学意义(P>0.05);治疗后,治疗组患者空腹血糖、餐后2 h血糖、糖化血红蛋白低于对照组,空腹C肽高于对照组(P<0.05)。治疗组患者血糖达标时间短于对照组,治疗费用低于对照组(P<0.05)。两组患者治疗期间均未出现明显不良反应。结论甘精胰岛素治疗老年2型糖尿病患者临床疗效确切,可有效降低血糖水平及治疗费用,缩短治疗时间,且安全性较高。
Objective To investigate the clinical efficacy and safety of insulin glargine in the treatment of type 2 diabetes in the elderly. Methods 100 cases of type 2 diabetic patients admitted to Urumchi Friendship Hospital in 2014-2016 were divided into control group and treatment group according to admission sequence, each with 50 cases. Patients in the control group were treated with recombinant human insulin and the patients in the treatment group were treated with insulin glargine for 14 days. The blood glucose (fasting blood glucose, fasting C-peptide, postprandial 2-hour blood glucose and glycosylated hemoglobin), the time of reaching the blood glucose and the treatment cost were compared between the two groups before and after treatment. The incidence of adverse reactions was observed. Results Before treatment, fasting blood glucose, fasting C-peptide, postprandial 2-h blood glucose and glycosylated hemoglobin were not significantly different between the two groups (P> 0.05). After treatment, the fasting blood glucose, postprandial blood glucose, Glycosylated hemoglobin was lower than that of the control group, fasting C-peptide was higher than the control group (P <0.05). Patients in the treatment group had shorter blood glucose time than the control group, and the cost of treatment was lower than that of the control group (P <0.05). No significant adverse reactions occurred in both groups during treatment. Conclusion Glargine treatment of elderly patients with type 2 diabetes clinical efficacy is exact, can effectively reduce blood sugar levels and treatment costs, shorten the treatment time, and high safety.