目的探讨妊娠期恶性淋巴瘤的治疗与胎儿宫内生长、分娩的相互影响及孕期处理。方法回顾性分析本院1例非霍奇金淋巴瘤(NHL)患者治疗及因特殊原因不能终止妊娠而成功分娩的经过,并分析妊娠期恶性淋巴瘤患者的治疗选择及对胎儿生长、母体结局的影响。结果妊娠期合并恶性淋巴瘤应及早进行治疗;对妊娠及母体的影响,包括流产、早产、胎死宫内及感染出血等。本例患者无法早期结束妊娠,靶向治疗联合化疗后,病变控制缓解,获得成功分娩。结论妊娠合并恶性淋巴瘤经过合理选择治疗,继续妊娠至胎儿成熟分娩,分娩后补充完成化、放疗,可获得良好的妊娠结局及母体生存。治疗对于婴儿的近远期影响在随访观察中。 Objective To explore the interaction between the treatment of malignant lymphoma in pregnancy and intrauterine growth and childbirth and the treatment during pregnancy. Methods We retrospectively analyzed the treatment of one non-Hodgkin’s lymphoma (NHL) in our hospital and the successful delivery due to special reasons that could not terminate the pregnancy. We analyzed the treatment options and prognosis of fetal growth, maternal outcome Impact. Results Pregnancy with malignant lymphoma should be treated as soon as possible; the impact on pregnancy and maternal, including miscarriage, premature delivery, intrauterine fetal death and infection bleeding. In this case, the patient could not finish the pregnancy early. After targeted therapy combined with chemotherapy, the disease control was relieved and the successful delivery was obtained. Conclusion Pregnancy with malignant lymphoma through a reasonable choice of treatment, to continue the pregnancy until the birth of the fetus, childbirth, replenishment, radiotherapy, to obtain a good pregnancy outcome and maternal survival. Short-term effects of treatment on infants were observed during follow-up.