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雌激素在卵巢癌进展中可能起着重要作用,但对其作用尚存在争议,这可能与雌激素受体类型有关。雌激素受体本身是有功能的,并能产生侵袭性。雌激素受体α的表达与卵巢癌分级、无进展生存期和病因特异性生存率相关。雌激素受体β的表达与淋巴结转移状态相关。血管发生是形成新生血管的过程,对于肿瘤生长、侵袭和转移至关重要。雌激素可能通过雌激素受体通路促进血管生成,从而在卵巢癌进展中发挥作用。
Estrogen may play an important role in the progression of ovarian cancer, but its role is still controversial, which may be related to the type of estrogen receptor. Estrogen receptors are themselves functional and can produce aggressiveness. The expression of estrogen receptor alpha is correlated with the grade of ovarian cancer, progression-free survival and etiology-specific survival rate. The expression of estrogen receptor beta is related to lymph node metastasis. Angiogenesis is a process of neovascularization that is crucial for tumor growth, invasion and metastasis. Estrogen may promote angiogenesis through the estrogen receptor pathway and thus play a role in the progression of ovarian cancer.