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10～20%Barrett食管是由于胃食管返流(GER)所致,10%患者易发生腺癌,迄今尚无有效药物治疗。奥美拉唑抑制壁细胞H~+/K~+-ATP酶,是一种强力长效抗胃酸分泌药物。作者给Barrett食管患者每日晨服一次奥美拉唑20mg。连服7天,并作有关指标测定,评价本药对这类患者GER的作用。方法在荧屏监控下将两个锑电极分别放置于食管下端括约肌(LES)以上5cm及以下10 cm处。腔内及皮肤相关电极连接于可携式pH计,测定胃和食管内pH值,电脑将其直接转换为H~+活性值。每分钟采样15次。研究对象包括14例经病史、内镜和组织学证实的Barrett食管患者,45例无并发症
10 to 20% of Barrett’s esophagus is due to gastroesophageal reflux (GER), 10% of patients are prone to adenocarcinoma, so far there is no effective drug treatment. Omeprazole inhibits parietal cells H ~ + / K ~ + -ATPase, is a potent long-term anti-gastric acid secretion drugs. The authors give omeprazole 20 mg daily to patients with Barrett’s esophagus. Even for 7 days, and for the determination of the relevant indicators to evaluate the drug on the role of GER in such patients. Methods Two antimony electrodes were placed on the lower esophageal sphincter (LES) 5 cm and below 10 cm under the screen monitor. The intracavitary and skin-related electrodes were connected to a portable pH meter, the pH in the stomach and esophagus was measured, and the computer converted it directly into H ~ + activity values. Sample 15 times per minute. The subjects included 14 patients with Barrett’s esophagus who were histologically, endoscopically and histologically confirmed, and 45 patients without complications