由于少量癌干细胞对放射治疗耐受,因此肿瘤经放疗后能复发。一项新的研究表明,放疗可使增殖的髓母细胞瘤细胞发生凋亡,但只能引起髓母细胞瘤干细胞发生细胞周期停滞,而利用小分子抑制剂可减小这种差异。作者选择了几种髓母细胞瘤小鼠模型进行研究,这些小鼠模型都是p53野生型(已 Due to the small number of cancer stem cells for radiation therapy tolerance, so the tumor can relapse after radiotherapy. A new study shows that radiotherapy can lead to apoptosis of proliferating medulloblastoma cells, but can only cause cell cycle arrest of medulloblastoma stem cells, and the use of small molecule inhibitors can reduce this difference. The authors selected several medulloblastoma mouse models that are all p53 wild-type