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目的:优化小檗碱-β-环糊精包合物的制备工艺。方法:以小檗碱-β-环糊精包合物的包合率和收率为考察指标,采用星点设计考察包合温度、包合时间以及主客分子投料比对包合工艺的影响,对结果进行多元线性回归、二次多项式和三次多项式拟合,并根据最佳数学模型进行预测。结果:多元线性回归方程的复相关系数较低,三次多项式拟合结果优于二次多项式拟合结果,小檗碱-β-环糊精包合物的最优包合工艺为β-环糊精与小檗碱的投料质量比3.65,包合时间4.5 h,包合温度64℃,包合率和收率预测值与理论值偏差分别为3.28%,2.63%。结论:星点设计-效应面法优化小檗碱β-环糊精包合物制备工艺具有很好的预测性。
Objective: To optimize the preparation of berberine-β-cyclodextrin inclusion compound. Methods: The inclusion rate and yield of berberine-β-cyclodextrin inclusion complex were used as indexes to investigate the effects of inclusion temperature, inclusion time and feeding ratio of host-guest molecules on the inclusion process. The results were multivariate linear regression, quadratic polynomial and cubic polynomial fitting, and based on the best mathematical model to predict. Results: The multiple correlation coefficients of the multiple linear regression equation were lower, the cubic polynomial fitting result was better than the quadratic polynomial fitting result. The optimal inclusion process of berberine-β-cyclodextrin inclusion complex was β-cyclodextrin The feed mass ratio of berberine to berberine was 3.65, the inclusion time was 4.5 h and the inclusion temperature was 64 ℃. The deviation between predicted and theoretical values of inclusion and yield were 3.28% and 2.63%, respectively. Conclusion: The method of star-point design-response surface optimization of berberine β-cyclodextrin inclusion complex preparation has good predictability.