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研究胃癌组织中MV计数 ,p53蛋白表达及其相互关系。方法 :胃癌组织中常规石蜡包埋切片 ,切片行常规ABC免疫组化染色。结果 :高分化、未淋巴结转移或未远处器官转移病例MV计数和 p53蛋白阳性率均明显低于低或未分化、淋巴结转移或远处器官转移病例 ;p53蛋白阳性病例MV计数明显高于p53蛋白阴性病例。结论 :MV计数和 p53蛋白表达可能是反映胃癌生物学行为、转移发生及预后的重要参数 ;p53蛋白具有促进胃癌MV生成 ,可能是胃癌MV生成的重要调节因素
To study the relationship between the expression of p53 and p53 protein in gastric cancer. Methods: Gastric cancer tissues were routinely paraffin embedded sections, routine ABC immunohistochemical staining. Results: The positive rates of MV and p53 in patients with well-differentiated, non-lymph node metastasis or distant metastasis were significantly lower than those with low or undifferentiated, lymph node metastasis or distant organ metastasis. The positive rate of p53 in p53-positive cases was significantly higher than that in p53 Protein negative cases. Conclusions: The expression of MV and p53 may be an important parameter to reflect the biological behavior, metastasis and prognosis of gastric cancer. P53 protein may promote the MV production of gastric cancer and may be an important regulator of gastric cancer MV formation