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目的:探讨广东省汉族妊娠期糖尿病(gestational diabetes mellitus,GDM)患者外周血miR-29、miR-375的表达情况及临床意义。方法:选取2012年12月~2013年5月在武警广东省总队医院就诊的90例GDM患者和糖耐量正常的孕妇,分别作为GDM组和对照组,检测血浆空腹胰岛素(fast insulin,FINS)及其外周血miR-29、miR-375的表达情况。结果:①GDM组及对照组的FINS分别为(15.67±5.75)mIU/L和(26.23±10.89)mIU/L(P<0.01);②GDM组外周血miR-29表达量(25.16±10.05)低于对照组(75.26±13.43)(P<0.05);③GDM组外周血miR-375的表达量(65.18±22.08)显著高于对照组(21.31±9.56)(P<0.05)。结论:GDM患者中miR-29、miR-375的异常表达与GDM易感性有一定相关。
Objective: To investigate the expression and clinical significance of miR-29 and miR-375 in peripheral blood of gestational diabetes mellitus (GDM) patients in Guangdong Province. Methods: Ninety GDM patients and pregnant women with normal glucose tolerance who were treated at the Corps Hospital of Guangdong Provincial Armed Police Corps from December 2012 to May 2013 were selected as GDM group and control group respectively. Fasting plasma insulin (FINS) and The peripheral blood miR-29, miR-375 expression. Results: The FINS of GDM group and control group were (15.67 ± 5.75) mIU / L and (26.23 ± 10.89) mIU / L respectively (P <0.01); ② The expression of miR-29 in peripheral blood of GDM group (75.26 ± 13.43) (P <0.05). ③The expression of miR-375 in peripheral blood of GDM group (65.18 ± 22.08) was significantly higher than that of control group (21.31 ± 9.56) (P <0.05). Conclusion: The abnormal expression of miR-29 and miR-375 in GDM patients is related to the susceptibility to GDM.