收集耳鼻喉头颈肿瘤门诊和其它几组头颈部鳞癌资料40287例，对二期恶性肿瘤的发生率，好发部位和发生时间进行分析，发现二期肿瘤的发生率为14．2畅，大多数H期肿瘤在原发癌诊断6个月后发生，且有沿消化或呼吸道轴发生的高度危险，其中喉癌多沿呼吸道发生，而日咽和其它恶性肿 Collected 40,287 cases of otolaryngologic head and neck cancer outpatients and other groups of head and neck squamous cell carcinoma data. The incidence, prevalence, and time of occurrence of stage 2 malignancy were analyzed. It was found that the incidence of stage 2 tumors was 14.2%. Most H-stage tumors occur 6 months after diagnosis of primary cancer, and are highly dangerous along the digestive or respiratory axis. Among them, laryngeal cancer mostly occurs along the respiratory tract, whereas pharynx and other malignancies occur.