目的:探讨克霉唑阴道片治疗妊娠期外阴阴道假丝酵母菌病的临床疗效。方法:收集我院2012年6月~2014年2月治疗的116例妊娠期外阴阴道假丝酵母菌病的患者,随机分成对照组和观察组各58例,两组患者在治疗前均用温水清洗外阴,对照组采用阴道给药制霉菌素1次/d,1次/片,连续治疗28d,观察组采用阴道给药0.5g克霉唑阴道片,1次/d,1次/片,连续治疗28d。结果:观察组治愈40例,显效8例,有效3例,无效7例,总有效率为87.3%,对照组治愈30例,显效10例,有效5例,无效13例,总有效率为77.6%,两组比较有统计学意义(P<0.05),经过治疗,观察组霉菌培养仍然阳性8例,占28.6%,其中白色假菌丝酵母菌5株,非白色假菌丝酵母菌3株,其中近平滑假菌丝酵母菌1株,热带假菌丝酵母菌1株,光滑假菌丝酵母菌1株。对照组霉菌培养仍然阳性16例,占57.1%,其中白色假菌丝酵母菌13株,非白色假菌丝酵母菌3株,其中近平滑假菌丝酵母菌1株,热带假菌丝酵母菌1株,光滑假菌丝酵母菌1株。结论:克霉唑阴道片的清除霉菌的清除率高,临床疗效显著,值得推广。 Objective: To investigate the clinical efficacy of clotrimazole vaginal tablets in the treatment of vulvovaginal candidiasis during pregnancy. Methods: A total of 116 cases of vulvovaginal candidiasis during pregnancy were collected from June 2012 to February 2014 in our hospital. All patients were randomly divided into control group and observation group of 58 cases. Both groups were treated with warm water The vulva was washed and the control group was treated with vaginal administration of nystatin once a day for 1 week, for continuous treatment for 28 days. The observation group was treated with intravaginal vaginal administration of 0.5 g clotrimazole vaginal tablets once daily, once daily, Continuous treatment 28d. Results: The observation group was cured 40 cases, 8 cases markedly effective, 3 cases effective, 7 cases ineffective, the total effective rate was 87.3%, the control group cured 30 cases, 10 cases markedly effective in 5 cases, ineffective in 13 cases, the total effective rate was 77.6 %, The two groups were statistically significant (P <0.05), after treatment, the observation group still positive mold culture in 8 cases, accounting for 28.6%, of which 5 strains of white fungus yeast, non-white pseudohyphae yeast 3 strains , Of which 1 strain of pseudohyphae subtilis, 1 strain of tropical pseudohtheriella and 1 strain of pseudomycoplasma. The control group still positive 16 cases of mold culture, accounting for 57.1%, of which 13 strains of pseudohyphae yeast, 3 strains of non-white pseudohyphae yeast, of which 1 pseudohyphae yeast, strain of tropical pseudohyphae yeast 1 strain, 1 pseudomonas yeast. Conclusion: Clotrimazole vaginal tablets removal of mold clearance rate, clinical efficacy is significant, it is worth promoting.