论文部分内容阅读
目的 分析东平县疑似预防接种异常反应(AEFI)发生特征,评价AEFI监测质量和预防接种安全性.方法 通过《中国免疫规划信息管理系统》、《全国AEFI信息管理系统》收集2010～2016年报告的AEFI个案和疫苗接种数据,用描述性流行病学方法进行统计分析.结果 2010～2016年接种疫苗2 229 126剂次,报告AEFI 590例,平均报告发生率为26. 47/10万剂.2010年报告覆盖率为43. 75％,2012年以来均达到100％;2010年48 h时内报告率为57. 14％,2012年以来均大于90％,2016年最高为99. 15％;2010～2016年,48 h内调查率、3 d内调查报告率均达到100％.AEFI病例中,一般反应574例(占97. 29％);异常反应9例(占1. 53％),报告发生率为0.39/10万剂,以卡介苗淋巴结炎、荨麻疹、血小板减少性紫癜为主.AEFI报告男女性别比为1.25: 1;其中2岁以下儿童占74.07％;AEFI个案主要分布在5～ 8、12月;接种疫苗0～1 d AEFI发生率占91.69％.结论 2010～2016年东平县AEFI监测质量逐年提高、预防接种安全性良好.“,”Objective To understand the occurrence features of adverse events following immunization (AEFI) in Dongping county and evaluate AEFI monitoring quality and safety of inoculation. Methods By Immune Planning Information Management System of China, The National AEFI Information Management System to collect reports of cases from 2010 to 2016 and vaccination data, and the data were analyzed by descriptive epidemiology method. Results A total of 2 229 126 doses of vaccine were received from 2010 to 2016, and 590 cases of AEFI were reported, with an average reported rate of 26. 47/105. In 2010, the coverage rate was 43. 75％, and since 2012, it has reached 100％. The reported rate in 48 h was 57. 14％ in 2010 and more than 90％ since 2012, and 99. 15％ in 2016. From 2010 to 2016, the reported rate in 48h and the investigated rate within 3d all reached 100％. In AEFI cases, 574 cases (97. 29％) were common, minor reactions. 9 cases(1. 53％) were rare serious reactions, and the reported incidence rate was 0. 39/105, mainly based on BCG lymphadenitis, urticaria and thrombocytopenic purpura. The AEFI ratio of male and female was 1. 25: 1; Children under 2 years of age accounted for 74. 07％; The AEFI cases were mainly distributed in 5-8 and 12 months. The incidence rate of 0-1 d AEFI was 91. 69％. Conclusion The monitoring quality of AEFI in Dongping county from 2010 to 2016 is improving and the safety of vaccination is good.