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目的通过研究筛选对冠心病具有最优诊断价值的血清脂蛋白,并评估血清脂蛋白作为冠心病预后及再生病症指标的可行性。方法采用病例-对照的方法进行研究,收集患者组与健康组的血清脂蛋白水平数据,其中患者组数据包括入院时、出院时,以及随诊时3个阶段发生与未发生病症两种情况下的生化水平,分别进行统计学分析,得出结果。结果冠心病患者血清中,TG、LDL-C、ApoB 3种脂蛋白水平均有显著升高,而HDL-C与ApoA1水平略有下降,LDLC、ApoA1和ApoB等3项脂蛋白水平作为诊断标准明显优于其他两种,综合考虑灵敏度和特异性两项指标,5项血清脂蛋白水平中最具诊断价值的为LDL-C水平;LDL-C和ApoB在任一时间段内对于发生和未发生病症的两组患者中,差异均具有统计学意义(P<0.05)。结论五项血清脂蛋白水平中最具诊断价值的为LDL-C水平;LDL-C和ApoB可作为冠心病患者再发生病症的监测指标,为临床上针对冠心病二级预防及预后情况提供了有利支持。
Objective To screen the serum lipoproteins with optimal diagnostic value for coronary heart disease and to evaluate the feasibility of serum lipoproteins as an index of prognosis and regeneration of coronary heart disease. Methods A case-control study was conducted to collect data on serum lipoprotein levels in patients and healthy subjects, including patient data on admission, discharge, and 3 stages of follow-up with and without illness Biochemical level, respectively, for statistical analysis, the results. Results Serum levels of TG, LDL-C and ApoB in patients with coronary heart disease were significantly increased (P <0.05), while the levels of HDL-C and ApoA1 were slightly decreased. The levels of three lipoproteins, LDLC, ApoA1 and ApoB, Obviously superior to the other two, considering both sensitivity and specificity, the most diagnostic value of the five serum lipoprotein levels is LDL-C level; LDL-C and ApoB are both positive and negative for any time period Two groups of patients with disease, the differences were statistically significant (P <0.05). Conclusions The most diagnostic value of the five serum lipoproteins is LDL-C level. LDL-C and ApoB can be used as monitoring indicators for the re-occurrence of coronary heart disease, providing a clinical basis for secondary prevention and prognosis of coronary heart disease Favorable support