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目的 探讨阻塞型睡眠呼吸暂停综合征患者脂蛋白 (a)及纤维蛋白原的变化及相互关系。方法 检测 4 0例阻塞型睡眠呼吸暂停综合征患者的脂蛋白 (a)水平与纤维蛋白原的改变 ,并设对照组。结果 阻塞型睡眠呼吸暂停综合征组脂蛋白 (a)水平 (中位数 )为 (2 82 5 8mg/L)较对照组 (15 2 5 2mg/L)显著升高 (P <0 0 1) ;阻塞型睡眠呼吸暂停综合征组纤维蛋白原为 (3 5 1± 1 12 ) g/L较对照组 (2 92± 0 94 ) g/L显著升高 (P <0 0 1) ;阻塞型睡眠呼吸暂停综合征与纤维蛋白原不存在正相关关系。结论 高水平的Lp(a)与纤维蛋白原是阻塞型睡眠呼吸暂停综合征的重要致病因素
Objective To investigate the changes and correlations of lipoprotein (a) and fibrinogen in patients with obstructive sleep apnea syndrome. Methods The levels of lipoprotein (a) and fibrinogen in 40 patients with obstructive sleep apnea syndrome were measured and compared with control group. Results The level of serum lipoprotein (a) in obstructive sleep apnea syndrome was significantly higher than that of the control group (152 82 mg / L) (P <0.01) ; Fibrinogen in obstructive sleep apnea syndrome group was significantly higher than that in control group (92 ± 0 94) g / L (P <0.01); obstructive Sleep apnea syndrome and fibrinogen do not have a positive correlation. Conclusions High levels of Lp (a) and fibrinogen are important risk factors for obstructive sleep apnea syndrome