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中耳和乳突在胚胎发育中来自第一咽囊,它们的上皮与呼吸道粘膜有关。正常人中耳粘膜含纤毛细胞、无纤毛细胞及基底细胞而无粘液细胞。作者观察慢性浆液性中耳炎患儿两例中耳和乳突粘骨膜病理变化。患儿分别为4岁和7岁。长期患该病并经数年常规治疗,包括增殖体刮除、鼓膜切开及反复置中耳通气管等。临床检查见鼓膜内陷、有瘢痕,鼓室积液明显。乳突摄片呈硬化型。乳突根治术中见鼓室贮积琥珀色粘液。切开鼓膜,以细小匙钳取中耳组织,及刮匙取乳突腔内增厚的粘骨膜。精细制备中耳和乳突粘膜标本。光镜下见粘膜上皮细胞呈立方形或柱状,有的有纤毛;常见单核细胞浸润,偶见成片浆细胞;可见泡沫状粘液细胞;偶有息肉或嗜伊红细胞和多核巨细胞。用油红染色(O R O)脂肪结果为阴性。中耳粘膜在电镜下较显著的变化是上皮细
The middle ear and papilla come from the first pharyngeal sac during embryonic development, and their epithelium is associated with the respiratory mucosa. Normal human middle ear mucosa containing ciliated cells, ciliated cells and basal cells without mucus cells. The authors observed two cases of chronic otitis media in children with middle ear and mastoid mucoperiosteal pathological changes. Children were 4 years old and 7 years old. Long-term suffering from the disease and after several years of routine treatment, including the proliferation of body curettage, tympanic membrane incision and repeatedly set the middle ear ventilation tube. Clinical examination showed tympanic membrane retraction, scarring, tympanic fluid obvious. Mastoid radiographs are sclerotic. Metastasis mastoid see tympanic storage of amber mucus. Cut the tympanic membrane, with a small spoon to take the middle ear tissue, and curettage take thickening of the mucocutaneous mucosa. Fine preparation of middle ear and mastoid mucosa specimens. Light microscope, mucosal epithelial cells were seen cubic or columnar, and some cilia; common mononuclear cell infiltration, occasionally into plasma cells; visible foamy mucus cells; occasionally polyps or eosinophils and multinucleated giant cells. Oil red staining (O R O) fat results were negative. Middle ear mucosa under electron microscopy more significant changes in epithelial thin