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目的:降低使用皮下埋植(皮埋)剂的副反应,提高继续使用率。方法:对4 559例合格入选的育龄妇女按不同体重随机分为减量皮埋组(减量组)2 243例,普通皮埋组(对照组)2 316例,观察5年各组的避孕效果、副反应和续用率。结果:随皮埋药量的减少,副反应逐渐减轻。月经紊乱减量组平均为28.0%,对照组平均为70.0%,两组比较有极显著性差异(P<0.01)。减量组和对照组的5年继续使用率平均分别为72.0%和50.0%,两组有极显著性差异(P<0.01)。两组5年累计妊娠率无显著性差异(P>0.05)。结论:减量皮下埋植剂避孕法既保持了普通皮下埋植剂避孕法的优势(长效、高效、可逆),又克服了普通皮埋法月经紊乱发生率高、影响续用率的缺点,可接受性好,同时又不使妊娠率有明显提高。
Objective: To reduce the use of subcutaneous implants (skin burying) agent side effects and improve the continued use rate. Methods: A total of 4 559 eligible women of childbearing age were randomly divided into two groups according to different body weights: 2243 cases of skin lesion reduction group (control group) and 2 316 cases of control group (control group) Effects, side effects, and renewal rates. Results: With the reduction of dermal burial dose, side effects gradually reduced. Menstrual disorders reduction group averaged 28.0%, the control group averaged 70.0%, there was a significant difference between the two groups (P <0.01). The average 5-year follow-up rates of the reduction group and the control group were 72.0% and 50.0% respectively, with significant difference between the two groups (P <0.01). There was no significant difference between the two groups in 5-year cumulative pregnancy rate (P> 0.05). Conclusion: The method of contraceptive implantation of subcutaneous implants not only maintains the advantages of contraceptive method (long-lasting, high-efficiency, reversible) but also overcomes the shortcomings , Acceptable, at the same time without significant increase in pregnancy rate.