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目的观察紫杉醇对食管癌三维适形放疗的增敏作用。方法将98例食管癌放疗患者随机分为增敏化疗组和对照组。对照组行单纯三维适形放射治疗,增敏化疗组在单纯放疗的基础上应用紫杉醇60mg静脉滴注,每周1次,直至放疗结束。观察两组疗效及生活质量。结果近期疗效总有效率(CR+PR)增敏化疗组100%,对照组93.8%;1年肿瘤局部控制率:增敏化疗组71.4%,对照组57.1%;放射性食管炎发生率:增敏化疗组56.7%,对照组31.6%。结论化疗药如紫杉醇等与放疗结合有协同/增敏作用,对中晚期食管癌而言放化疗结合的疗效优于单纯放疗,并且不明显增加放疗的毒副作用。
Objective To observe the sensitizing effect of paclitaxel on esophageal carcinoma three-dimensional conformal radiotherapy. Methods 98 cases of esophageal cancer radiotherapy patients were randomly divided into sensitization chemotherapy group and control group. The control group received simple three-dimensional conformal radiotherapy. On the basis of radiotherapy alone, the sensitization and chemotherapy group was given paclitaxel 60 mg intravenously once a week until the end of radiotherapy. The curative effect and quality of life of the two groups were observed. Results The total effective rate (CR + PR) in the short term was 100% in the sensitized group and 93.8% in the control group. The local control rate in 1 year was 71.4% in the sensitized group and 57.1% in the control group. The incidence of radiation esophagitis was: Chemotherapy group 56.7%, control group 31.6%. Conclusion Chemotherapy drugs such as paclitaxel and radiotherapy combined with synergistic / sensitizing effect on the treatment of advanced esophageal cancer in combination with radiotherapy and chemotherapy is superior to radiotherapy alone, and does not significantly increase the side effects of radiotherapy.