目的探索复发性流产夫妇中男性患者的遗传异常情况,为临床诊治和咨询奠定基础。方法回顾性分析2013年5月至2016年5月在我院生殖中心复发性流产门诊就诊的男性患者,对其1162例男性患者纳入研究,对其外周血进行淋巴细胞培养,G显带染色体核型分析。结果在1162例男性患者中有68例存在染色体结构和数目异常,其中性染色体数目异常为4例,性染色体结构异常有19例,常染色体结构异常的有45例,此外,全部1162例患者中的染色体多态改变有87例。结论复发性流产夫妇中男性患者的染色体核型异常的发生率较高,对其进行染色体核型分析,有助于对病因的诊断以及遗传咨询。 Objective To explore the genetic abnormalities of male patients with recurrent spontaneous abortion and lay the foundation for clinical diagnosis and counseling. Methods A retrospective analysis of male patients admitted to the recurrent abortion clinics of our reproductive center from May 2013 to May 2016 was included in the study of 1162 male patients. Lymphocytes were cultured in peripheral blood, G-banding chromosomes Type analysis Results Of the 1162 male patients, 68 had abnormal chromosome structure and number. There were 4 cases of abnormal chromosome number, 19 cases of sex chromosome abnormality and 45 cases of autosomal abnormality. In addition, among 1162 cases Chromosome polymorphism in 87 cases. Conclusions Male patients with recurrent spontaneous abortion have a higher incidence of chromosomal abnormalities in karyotypes. Chromosomal karyotype analysis may be helpful for the diagnosis of patients and genetic counseling.