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目的:探讨湖北地区肾移植受者与HLA基因相关性。方法:运用PCR-SSP法对我院湖北地区406例肾移植受者(观察组)进行HLA-ABDR基因分型并计算其基因频率,并与4026例湖北骨髓库健康人(对照组)比较。结果:观察组中检出HLA-A32、B35、B44、B45、B52、B56、B64、B75、DRB1*10、DRB1*14、DRB1*16,基因频率显著高于对照组(P<0.05),其中B35、DRB1*14的基因频率>0.05;检出B46、DRB1*9、DRB1*17基因频率显著低于对照组(P<0.05),其中B46、DRB1*9基因频率>0.1。结论:高频率基因与湖北地区健康人群基因频率基本一致,其中B35、DRB1*14等位基因可能是湖北地区的易感基因;B46、DRB1*9等位基因可能是保护基因。
Objective: To investigate the correlation between HLA-related genes and renal allograft recipients in Hubei Province. Methods: The HLA-ABDR genotypes of 406 renal transplant recipients (observation group) in Hubei province were analyzed by PCR-SSP method and the frequency of HLA-ABDR gene was calculated and compared with that of 4026 Hubei bone marrow patients (control group). Results: The frequencies of HLA-A32, B35, B44, B45, B52, B56, B64, B75, DRB1 * 10, DRB1 * 14 and DRB1 * 16 in the observation group were significantly higher than those in the control group The frequencies of B46, DRB1 * 9 and DRB1 * 17 genes were significantly lower than those of the control group (P <0.05). The frequency of B46 and DRB1 * 9 genes was> 0.1. Conclusion: The frequency of high frequency gene is basically consistent with that of healthy people in Hubei Province. The B35 and DRB1 * 14 alleles may be the susceptible genes in Hubei Province. The B46 and DRB1 * 9 alleles may be protective genes.