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目的探讨血清脂氧素A4(LXA4)、可溶性血管细胞黏附分子-1(sVCAM-1)、肿瘤坏死因子-α(TNF-α)在过敏性紫癜(HSP)患儿表达的意义。方法采用双抗体夹心酶联免疫吸附法分别测定56例HSP患儿及25例健康儿童(对照组)血清LXA4、sVCAM-1和TNF-α含量,分别比较其急性期和恢复早期上述因子表达水平。结果 HSP患儿急性期和恢复早期血清LXA4、sVCAM-1、TNF-α水平均显著高于对照组;HSP患儿急性期血清sVCAM-1和TNF-α水平均显著高于恢复早期;而血清LXA4水平明显低于恢复早期(P﹤0.01)。结论 sVCAM-1、TNF-α可能参与HSP发病过程,而LXA4可能有抗炎作用。
Objective To investigate the expression of serum lipoxin A4 (LXA4), soluble vascular cell adhesion molecule-1 (sVCAM-1) and tumor necrosis factor-α (TNF-α) in children with Henoch-Schonlein purpura Methods Serum levels of LXA4, sVCAM-1 and TNF-α in 56 children with HSP and 25 healthy children (control group) were measured by double antibody sandwich enzyme-linked immunosorbent assay. The expression levels of these factors in acute phase and early recovery phase were compared respectively . Results The levels of serum LXA4, sVCAM-1 and TNF-α in acute and early recovery stage of HSP were significantly higher than those in control group. The levels of sVCAM-1 and TNF-α in acute stage of HSP were significantly higher than those in early stage of recovery; LXA4 levels were significantly lower than early recovery (P <0.01). Conclusion sVCAM-1 and TNF-α may be involved in the pathogenesis of HSP, while LXA4 may have anti-inflammatory effects.