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目的探讨妊高征患者凝血与纤溶指标的变化及其临床意义。方法对63例妊高征患者、86例正常妊娠妇女和51例正常非妊娠妇女的血液采用凝固法测定PT、APTT、FVIIa、FVIIIa、FIXa,透射免疫比浊法测定FBG,仪器法测定PLT和酶联免疫吸附法测定D-D等,比较各检测指标在不同组别中的差异。结果正常妊娠妇女PT、APTT均缩短,FBG、FVIIa、FVIIIa、FIXa、D-D等升高,与正常非妊娠妇女(正常组)比较,差异有统计学意义(P<0.05);妊高征患者与正常妊娠妇女变化相同,但各指标变化程度加大,且随病情加重而加剧,血小板亦下降。结论妊高征患者凝血与纤溶指标监测,对预测妊高征的进一步发展具有重要意义。
Objective To investigate the changes and clinical significance of coagulation and fibrinolysis in patients with pregnancy induced hypertension. Methods PT, APTT, FVIIa, FVIIIa and FIXa were determined by coagulation assay in 63 patients with PIH, 86 normal pregnant women and 51 normal nonpregnant women. Transmission electron microscopy was used to detect FBG, DD, etc. were compared by enzyme-linked immunosorbent assay (ELISA), and the difference of each test index in different groups was compared. Results Compared with normal nonpregnant women (normal group), the levels of PT, APTT, FBG, FVIIa, FVIIIa, FIXa and DD in normal pregnant women were significantly higher than those in normal pregnant women (P <0.05) Normal pregnancy women change the same, but the degree of change of the indicators increased, and aggravated with the aggravation of the disease, platelets also declined. Conclusion The monitoring of coagulation and fibrinolysis in patients with PIH is of great significance in predicting the further development of PIH.